CONGENITAL MYATHENIC SYNDROME Acute coronary syndrome Mouse models Hypoxia Mice Cell model Centronuclear myopathy RNA splicing Myelin Brain dysfunction Exercise Transgenic mouse Motoneuron Intermediate filament Cardiac muscle Expression Gene editing Myotonic Dystrophy Dystrophin Exercice Desmin DM1 Neuron Transgenic mouse model Autophagy Thérapie génique Fibrosis Diaphragm PCR Acetylcholinesterase knockout mouse Transcriptomics Myotonic dystrophy mouse models AAV RNA interference GABA Central nervous system CRISPR/Cas9 PacBio Muscular dystrophy ARN Maximal force Long read sequencing Duchenne muscular dystrophy Glial cells DMSXL mice ACETYLCHOLINESTERASE Brain Trinucleotide Repeat Expansion CRISPRi Cell culture model Astrocytes Gene therapy Glutamate Dystrophie Myotonique CMS Quantitative microdialysis Mouse model BIOLOGIE MOLECULAIRE Cell penetrating peptide In vivo CTG repeat contractions Glucocorticoid-receptor Myostatin Trinucleotide repeat expansion Astrocyte Heart MBNL Alternative splicing Male Endurance training CTG repeats GSK3␤ Therapy Heart failure Antisense oligonucleotides Myotonic dystrophy Dystrophie myotonique Humans Gene Therapy Acetylcholinesterase deficiency Myotonic dystrophy type 1 Glucocorticoids Genotype phenotype correlation Oligodendrocytes Myotonic Dystrophy Type 1 Oligodendrocyte Skeletal muscle Dynamin 2 Knockout DMPK Myotonic Dystrophy type 1 Antisense oligonucleotide Aging Muscle KNOCKOUT MICE Animals Dilated cardiomyopathy Cytoskeleton CTG repeat instability RNA biology